Lines of evidence supporting the role of an extreme thermo-acidophilic bacterium (spiroplasma sp.) in the pathogenesis of chronic wasting disease and the other transmissible spongiform encephalopathies.
MORPHOLOGICAL
- SPIROPLASMA IDENTIFIED BY TEM IN CJD BRAIN TISSUES
- SPIROPLASMA IN AQUEOUS FLUID OF SHEEP WITH TERMINAL SCRAPIE
- EXPERIMENTALLY SPIROPLASMA-INFECTED ANIMAL MODEL
- SPIROPLASMA INDUCES SPONGIFORM ENCEPHALOPATHY
- CLINICAL EVIDENCE OF BRAIN STEM LESIONS
- MORPHOLOGICAL EVIDENCE OF BRAIN STEM LESION
- MORPHOLOGICAL EVIDENCE OF BRAIN STEM LESION
- LOCALIZATION TO EYES- RETINOPATHY
- CULTURE OF SPIROPLASMA FROM CWD & OTHER TSE-AFFECTED TISSUES
- PASSAGE IN EMBRYONATED EGGS
- GROWTH ON AGAR WITH FORMATION OF SUBSURFACE PLAQUES
- IDENTICAL BIOLOGICAL CHARACTERISTICS OF TRANSMISSIBLE TSE AGENT AS SHOWN BY ENUMERATION OF SUBSURFACE PLACUES ON AGAR
- REACTION OF SCRAPIE HYPERIMMUNE SERA WITH SPIROPLASMA FIBRILS
- ELISA REACTION OF SPIROPLASMA RECOMBINANT HSP60 WITH CJD SERA
- FORMATION OF ALPHA SYNUCLEIN IN SPIROPLASMA MIRUM INFECTED MAMMALIAN TISSUE CULTURE
- NORMAL PRION PROTEIN ISOFORM ON CELL SURFACE IS RECEPTOR FOR BACTERIUM-EXPLAINS INTERACTION OF PRION WITH SPIROPLASMA